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Across 3. When the active site of an enzyme changes its shape. 5. Enzymes work within a narrow range of this. Too high or too low and enzymes are denatured. 6. The word used to describe the perfect temperature or pH for an enzyme to work. 9. The part of the enzyme where the substrate fits. (2 Words) 10. The molecule the enzyme works on. 11. Enzyme in the mouth that digests starch. 12. Enzyme that digests protein in the stomach.

Down 1. Biological catalysts which control the rate of metabolic reactions. 2. This factor controls reactions, if too high enzymes get denatured. 4. The model which describes how enzymes work. (3 Words) 7. Enzymes that digest proteins. 8. Enzymes that digest lipids.