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Across 2. Immunoglobulin D is present in _________ surface 5. It provides protection against viruses and bacteria and neutralizes bacterial toxins 6. It is located in body secretions, including tears, saliva, breast milk, and colostrum 7. Immunoglobulin G is responsible for _________ immune response 8. Immunoglobulins are also knows as ___________ 10. Immunoglobulin A binds antigens on _________ before they invade tissues 12. It plays a role in the introduction of antibody production 13. Immunoglobulin M is involved in the _________ blood group 15. Immunoglobulin E assists in defense against _________ infections 16. The assessment of the immunoglobulin isotype can provide useful insight into complex _________ immune response 17. Immunoglobulin M is responsible for _________ immune responses 18. Various antibodies are produced by _________ cells

Down 1. Determination of individual subclasses is relevant in assessing primary _________ or immune responses 3. How many antibody classes have been identified in placental mammals? 4. They act as critical part of the immune response by specifically recognizing and binding to particular antigens such as bacteria and viruses 6. Its main function is to stop parasites 9. Assessment and knowledge of immunoglobulin structure and classes is also important for selection and preparation of antibodies as tools for _________ and other detection applications 11. It has two successive domains: one constant domain and one variable domain 13. The _________ immune response is highly complex and exceedingly specific 14. The light chains are always either both kappa or both _________