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Across 3. What was the name of the female scientist who discovered artemisinin? 5. In 2015, what prize did her and her team win for their discovery? 6. What is the name given to the study of plants? 10. Where can you find artemisinin in nature? 12. The team initially had issues with artemisinin extractions because the active compound is heat labile. This means it is sensitive to …? 13. What disease does the drug artemisinin treat? 14. Because of the higher toxicity of the acidic portion the team continued working on the neutral portion. Why were these toxicity results causing issues? 15. What is the Chinese name for artemisinin? 16. To refine her plant extract, what two portions did Tu first separate out in her studies? (2) 17. How was the structure of artemisinin finally discovered? 18. To refine her plant extract, what two portions did Tu first separate out in her studies? (1) 19. What did Tu study at the University of Peking?

Down 1. In what animal was the drug first tested for efficacy against malaria? 2. What drug was previously used to treat the disease artemisinin acts against? 4. To overcome this and finally prove the safety of their drug (even at higher doses), who did the researchers test the drug on? 7. Plants and fungi are very good sources for drugs and antibiotics, what do they usually use the compounds as? 8. How come a new drug was so desperately needed? 9. Where is YouYou Tu from? 11. How can artemisinin be purified from plant extracts? 12. What do you call an animal that eats only plants?